Julian A. Hiscox
Infection and Global Health, University of Liverpool, U.K.

Viruses are dependent on the host cell in order to replicate and infection can be seen as a battleground between the pro-viral recruitment of cellular proteins involved in replication, the triggering of anti-viral responses and virus subversion of this pathway. High throughput quantitative proteomics can be used to capture this dynamic interplay throughout infection, allowing the simultaneous identification and measurement of many thousands of proteins, both cellular and viral. This presentation will describe how such technology has been used to provide deeper functional insights into virus biology and allow the development of small molecule inhibitors of virus function that can be used therapeutically, and as consequence how the function of individual virus proteins can be rapidly elucidated, and as part of this, used in diagnostic reagents.