Liu,jikai
Mushrooms in bio-resources belong to the very productive biologically sources which produce a large and diverse variety of secondary metabolites. We have been interested in the biologically active substances present in untapped and diverse source of mushrooms from west China. In order to search for naturally occurring bioactive metabolites from higher fungi we investigated the chemical constituents of more than 200 mushrooms in China since last 15 years. More than 2000 compounds including 500 novel toxin, pigments, bioactive compounds belong to nitrogen-containing compounds (including unique amino acids), terpenoids, polyketides, and phenolics were isolated from basidiomycetes and ascomycetes. Some of them showed very interesting pharmacological activities. The isolation, structural elucidation and biologically activity of the new compounds are discussed. |